Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.32 |
| ▸ | CA4 | P22748 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL2425700 | 0.95 | LMNA (0.53) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL30107666 | 0.94 | LMNA (0.59) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL8986952 | 0.90 | TSHR (0.52) | LMNAALOX15HSD17B10TSHRTP53 | |
| Fumaric Acid SCHEMBL2389920 | 0.88 | LMNA (0.39) | LMNAALOX15TSHRALDH1A1CA1 | |
| Acrylic Acid SCHEMBL4277400 | 0.88 | LMNA (0.67) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL15608360 | 0.85 | LMNA (0.62) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL27591473 | 0.84 | LMNA (0.71) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL9769250 | 0.84 | LMNA (0.71) | LMNAALOX15HSD17B10TSHRTP53 | |
| Acrylic Acid SCHEMBL9769256 | 0.84 | LMNA (0.71) | LMNAALOX15HSD17B10TSHRTP53 | |
| Maleic Acid SCHEMBL2381432 | 0.82 | TSHR (0.53) | LMNAALOX15HSD17B10TSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023276648-A1 | LIQUID COMPOSITION FOR SILICONE RUBBER SPHERICAL PARTICLES, SILICONE RUBBER SPHERICAL PARTICLES AND PRODUCTION METHOD THEREFOR, AND SILICONE COMPOSITE PARTICLES AND PRODUCTION METHOD THEREFOR | 信越化学工業株式会社 | 2023-01-05 | — | — | WO | disclosed |
| CN-115108947-A | Strong detergency alkyl polyoxyethylene ether benzene sulfonic acid and its salt and use | 广州市浪奇实业股份有限公司 | 2022-09-27 | — | — | CN | disclosed |
| US-20210238422-A1 | POROUS SPHERICAL SILICONE RUBBER PARTICLES, POROUS SILICONE COMPOSITE PARTICLES, AND METHOD FOR PRODUCING THESE PARTICLES | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2021-08-05 | — | — | US | disclosed |
| EP-3848407-A1 | POROUS SPHERICAL SILICONE RUBBER PARTICLES, POROUS SILICONE COMPOSITE PARTICLES, AND METHOD FOR PRODUCING THESE PARTICLES | SHIN-ETSU CHEMICAL CO., LTD. (JP) | 2021-07-14 | — | — | EP | disclosed |
| CN-102257117-B | Laundry detergent composition | UNILEVER NV | 2014-12-03 | — | — | CN | disclosed |
| CN-102257117-A | Laundry detergent composition | UNILEVER NV | 2011-11-23 | — | — | CN | disclosed |