SCHEMBL23904669

SCHEMBL23904669

N#Cc1cc(I)cc2c1N(CCCOCc1ccccc1)CC2

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTSL P07711 1/20 0.37
CTSB P07858 1/20 0.37
CTSK P43235 1/20 0.37
TEAD3 Q99594 2/20 0.36
HRH3 Q9Y5N1 3/20 0.36
LTA4H P09960 1/20 0.34
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
KDM4E B2RXH2 1/20 0.34
HPGD P15428 1/20 0.34
AOC3 Q16853 1/20 0.34
MAOB P27338 1/20 0.33
GBA1 P04062 1/20 0.33
UGCG Q16739 1/20 0.33
GBA2 Q9HCG7 1/20 0.33
ADRA1D P25100 1/20 0.33
ADRA1A P35348 1/20 0.33
ADRA1B P35368 1/20 0.33
CHRNA7 P36544 2/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3341412 0.87 CTSL (0.37) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL23912977 0.87 L3MBTL1 (0.39) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL15934399 0.85 HRH3 (0.36) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL4537574 0.85 TEAD3 (0.39) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL16749903 0.84 ADRA1D (0.41) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL17502988 0.82 ADRA1D (0.42) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL3342398 0.82 TEAD3 (0.39) TEAD3HRH3MEN1KMT2AKDM4E
SCHEMBL12247877 0.82 ADRA1D (0.42) CTSLCTSBCTSKTEAD3HRH3
SCHEMBL16749902 0.80 ADRA1D (0.44) TEAD3MEN1KMT2AADRA1DADRA1A
SCHEMBL12816498 0.80 ADRA1D (0.44) TEAD3MEN1KMT2AADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3892615-A1 PROCESS FOR THE PREPARATION OF SILODOSIN Minakem (FR) 2021-10-13 EP disclosed
EP-3892615-A1 PROCESS FOR THE PREPARATION OF SILODOSIN Minakem (FR) 2021-10-13 EP disclosed