SCHEMBL23912018

SCHEMBL23912018

N#Cc1c(-n2c3ccc(-n4c5ccccc5c5ccccc54)cc3c3cc(-n4c5ccccc5c5ccccc54)ccc32)cc(-c2cccnc2-c2cccc(-c3ccccc3)c2)cc1-n1c2ccc(-n3c4ccccc4c4ccccc43)cc2c2cc(-n3c4ccccc4c4ccccc43)ccc21

nearest known ligand 0.32

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
TDO2 P48775 1/20 0.32
CYP11B2 P19099 1/20 0.32
ALDH1A1 P00352 2/20 0.32
HTT P42858 1/20 0.32
HSD17B10 Q99714 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.30
KDM4E B2RXH2 1/20 0.30
ATM Q13315 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30
LMNA P02545 1/20 0.30
HPGD P15428 1/20 0.30
MAPK1 P28482 1/20 0.30
RECQL P46063 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20619468 0.92 PTGS1 (0.32) CYP11B2ALDH1A1HTTHSD17B10SMN1; SMN2
SCHEMBL23912036 0.90 BCHE (0.33) TDO2CYP11B2ALDH1A1HTTHSD17B10
SCHEMBL23912034 0.90 ALDH1A1 (0.35) CYP11B2ALDH1A1HTTHSD17B10SMN1; SMN2
SCHEMBL20619697 0.88 CYP11B2 (0.34) CYP11B2ALDH1A1HTTHSD17B10SMN1; SMN2
SCHEMBL20620055 0.87 BCHE (0.35) TDO2ALDH1A1HTTHSD17B10SMN1; SMN2
SCHEMBL20620051 0.87 CYP11B2 (0.33) TDO2CYP11B2ALDH1A1HTTHSD17B10
SCHEMBL20619476 0.87 PTGS1 (0.38) CYP11B2ALDH1A1HTTHSD17B10KDM4E
SCHEMBL20619449 0.86 TDO2 (0.38) TDO2CYP11B2
SCHEMBL20619481 0.85 ADORA1 (0.35) TDO2CYP11B2ALDH1A1HTTHSD17B10
SCHEMBL23912047 0.85 SQOR (0.35) TDO2ALDH1A1HSD17B10LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3645522-B1 ORGANIC MOLECULES, IN PARTICULAR FOR USE IN OPTOELECTRONIC DEVICES CYNORA GMBH (DE) 2021-10-13 EP disclosed