SCHEMBL23924702

SCHEMBL23924702

CC(C)(C)OC(=O)N1CC(CN(C(=O)OCC2c3ccccc3-c3ccccc32)C2CC2)C1

nearest known ligand 0.41

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NAMPT P43490 1/20 0.41
GPR119 Q8TDV5 3/20 0.39
IDO1 P14902 4/20 0.39
BACE1 P56817 1/20 0.38
USP30 Q70CQ3 2/20 0.38
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38
KDM4E B2RXH2 1/20 0.37
PKM P14618 1/20 0.37
ALOX5AP P20292 1/20 0.36
FEN1 P39748 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30267608 1.00 NAMPT (0.41) NAMPTGPR119IDO1BACE1USP30
SCHEMBL23930395 0.86 FABP5 (0.40)
SCHEMBL15297397 0.83 USP30 (0.41) NAMPTGPR119IDO1BACE1USP30
SCHEMBL25228434 0.83 BACE1 (0.40) NAMPTGPR119IDO1BACE1KDM4E
SCHEMBL25276658 0.82 IDO1 (0.41) NAMPTGPR119IDO1BACE1USP30
SCHEMBL31688597 0.82 NAMPT (0.42) NAMPTIDO1BACE1USP30JAK2
SCHEMBL3580338 0.82 GPR119 (0.44) GPR119IDO1BACE1USP30JAK2
SCHEMBL25657529 0.80 KMT2A (0.39)
SCHEMBL25797253 0.80 KMT2A (0.41)
SCHEMBL15297396 0.79 JAK2 (0.39) NAMPTGPR119IDO1BACE1USP30

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210323946-A1 PROCESS FOR PREPARING A PHTHALAZINONE DERIVATIVE AND INTERMEDIATES THEREOF IDIENCE CO., LTD. (KR) 2021-10-21 US claimed
US-12060345-B2 Process for preparing a phthalazinone derivative and intermediates thereof IDIENCE CO., LTD. (KR) 2024-08-13 US disclosed
US-11691964-B2 Crystalline forms of phthalazinone compound ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-07-04 US disclosed
EP-4139297-A1 CRYSTALLINE FORMS OF PHTHACAZ1NONF COMPOUND Idience Co., Ltd. (KR) 2023-03-01 EP disclosed
US-20220372020-A1 CRYSTALLINE FORMS OF PHTHALAZINONE COMPOUND IDIENCE CO., LTD. (KR) 2022-11-24 US disclosed
US-11390608-B2 Crystalline forms of phthalazinone compound IDIENCE CO., LTD. (KR) 2022-07-19 US disclosed
WO-2021214503-A1 CRYSTALLINE FORMS OF PHTHACAZ1NONF COMPOUND IDIENCE CO., LTD. (KR) 2021-10-28 WO disclosed
US-20210323946-A1 PROCESS FOR PREPARING A PHTHALAZINONE DERIVATIVE AND INTERMEDIATES THEREOF IDIENCE CO., LTD. (KR) 2021-10-21 US disclosed
US-20210323945-A1 CRYSTALLINE FORMS OF PHTHALAZINONE COMPOUND IDIENCE CO., LTD. (KR) 2021-10-21 US disclosed
US-20210323946-A1 PROCESS FOR PREPARING A PHTHALAZINONE DERIVATIVE AND INTERMEDIATES THEREOF IDIENCE CO., LTD. (KR) 2021-10-21 US disclosed
US-20170037316-A1 LIQUID-CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2017-02-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220372020-A1 CRYSTALLINE FORMS OF PHTHALAZINONE COMPOUND H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC1, UACA NAMPT 2227/4885GPR119 1083/4885IDO1 3418/4885
US-20170037316-A1 LIQUID-CRYSTALLINE MEDIUM FES, NEFM, SOST NAMPT 875/4885GPR119 2720/4885IDO1 1940/4885
US-11390608-B2 Crystalline forms of phthalazinone compound H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC1, UACA NAMPT 2227/4885GPR119 1083/4885IDO1 3418/4885
US-20210323945-A1 CRYSTALLINE FORMS OF PHTHALAZINONE COMPOUND H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC1, UACA NAMPT 2227/4885GPR119 1083/4885IDO1 3418/4885
US-12060345-B2 Process for preparing a phthalazinone derivative and intermediates thereof AZI2, NISCH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 NAMPT 1520/4885GPR119 2747/4885IDO1 2033/4885
US-11691964-B2 Crystalline forms of phthalazinone compound H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, RCC1, UACA NAMPT 2227/4885GPR119 1083/4885IDO1 3418/4885
US-20210323946-A1 PROCESS FOR PREPARING A PHTHALAZINONE DERIVATIVE AND INTERMEDIATES THEREOF NISCH, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, DHPS NAMPT 837/4885GPR119 2605/4885IDO1 2349/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.