Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | TTR | P02766 | 1/20 | 0.30 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylene Chloride SCHEMBL28020824 | 0.85 | POLB (0.31) | POLBLMNA | |
| Succinic Acid SCHEMBL28916613 | 0.83 | LMNA (0.45) | TSHRCA12CA1CA9ALDH1A1 | |
| Succinic Acid SCHEMBL722926 | 0.83 | LMNA (0.45) | TSHRCA12CA1CA9ALDH1A1 | |
| SCHEMBL6742810 | 0.82 | CA12 (0.35) | CA12CA1CA9ALDH1A1PKM | |
| 1,2-Dichloroethane SCHEMBL28194159 | 0.82 | POLB (0.31) | POLB | |
| Bicarbonate SCHEMBL14917 | 0.82 | CA1 (0.38) | TSHRCA12CA1CA9ALDH1A1 | |
| Bicarbonate SCHEMBL6150295 | 0.82 | CA1 (0.38) | TSHRCA12CA1CA9ALDH1A1 | |
| Thioglycolic Acid SCHEMBL7061183 | 0.81 | TSHR (0.33) | TSHRCA12CA1CA9ALDH1A1 | |
| Propionic Acid SCHEMBL1518988 | 0.81 | FFAR3 (0.48) | TSHRCA12CA1CA9ALDH1A1 | |
| Glycine SCHEMBL1681950 | 0.81 | GLRA1 (0.48) | TSHRCA12CA1CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230242586-A1 | RAS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2023-08-03 | — | — | US | disclosed |
| EP-4138875-A1 | RAS INHIBITORS AND USES THEREOF | The Regents of the University of California (US) | 2023-03-01 | — | — | EP | disclosed |
| WO-2021217019-A1 | RAS INHIBITORS AND USES THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-10-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230242586-A1 | RAS INHIBITORS AND USES THEREOF | KRAS, NRAS, HRAS | TSHR 3074/4885CA12 3997/4885CA1 4528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.