Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | SDCBP | O00560 | 2/20 | 0.35 |
| ▸ | SDC2 | P34741 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24160213 | 0.89 | THRB (0.38) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL23129062 | 0.89 | MAPT (0.40) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL13258696 | 0.88 | THRB (0.38) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL23739877 | 0.88 | MAPT (0.38) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL26289667 | 0.87 | KMT2A (0.37) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL26443198 | 0.85 | ALDH1A1 (0.36) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL23739470 | 0.85 | LMNA (0.36) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL21848620 | 0.83 | THRB (0.34) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL23298823 | 0.83 | KDM4E (0.36) | ALDH1A1THRBMAPTLMNAMEN1 | |
| SCHEMBL25900444 | 0.83 | MAPT (0.42) | ALDH1A1THRBMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3896062-A1 | ISOINDOLINE COMPOUND, AND PREPARATION METHOD, PHARMACEUTICAL COMPOSITION, AND APPLICATION OF ISOINDOLINE COMPOUND | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2021-10-20 | — | — | EP | disclosed |