Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23940249 | 0.86 | BRD4 (0.55) | LMNACREBBPHDAC1HDAC2BRD4 | |
| SCHEMBL23940201 | 0.85 | HDAC1 (0.56) | LMNAHDAC1HDAC2BRD4ALDH1A1 | |
| SCHEMBL22810517 | 0.84 | LMNA (0.46) | LMNACREBBPHDAC1HDAC2BRD4 | |
| SCHEMBL23940222 | 0.83 | KMT2A (0.47) | LMNACREBBPHDAC1HDAC2BRD4 | |
| SCHEMBL23940243 | 0.82 | ALDH1A1 (0.59) | CREBBPHDAC1HDAC2KDM4EALDH1A1 | |
| SCHEMBL23940144 | 0.81 | CREBBP (0.49) | LMNACREBBPHDAC1HDAC2KDM4E | |
| SCHEMBL23940135 | 0.80 | HTR3A (0.45) | NAMPTCNR1CNR2 | |
| SCHEMBL23940153 | 0.78 | ALDH1A1 (0.50) | KDM4EALDH1A1SMN1; SMN2CNR1CNR2 | |
| SCHEMBL23940236 | 0.78 | CREBBP (0.51) | LMNACREBBPKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL15458754 | 0.76 | SMN1; SMN2 (0.51) | LMNACREBBPBRD4KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | TYK2, JAK3, JAK1 | LMNA 4049/4885CREBBP 1002/4885HDAC1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.