Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | RHEB | Q15382 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | THRA | P10827 | 3/20 | 0.31 |
| ▸ | THRB | P10828 | 3/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966809 | 0.72 | IKBKE (0.38) | — | |
| SCHEMBL23966550 | 0.72 | CNR2 (0.32) | PPARG | |
| SCHEMBL23966541 | 0.67 | DGAT1 (0.32) | SMN1; SMN2MEN1KMT2ALMNAMAPK1 | |
| SCHEMBL23914589 | 0.66 | SCN9A (0.33) | MEN1KMT2ALMNAMAPK1TP53 | |
| SCHEMBL2038965 | 0.64 | THRA (0.47) | SMN1; SMN2MEN1KMT2AALDH1A1THRA | |
| SCHEMBL197292 | 0.63 | THRA (0.49) | SMN1; SMN2MEN1KMT2ALMNATHRA | |
| SCHEMBL2053781 | 0.63 | THRA (0.49) | SMN1; SMN2MEN1KMT2ALMNATHRA | |
| SCHEMBL2049161 | 0.63 | THRA (0.49) | SMN1; SMN2MEN1KMT2ALMNATHRA | |
| SCHEMBL339836 | 0.63 | THRA (0.49) | SMN1; SMN2MEN1KMT2ALMNATHRA | |
| SCHEMBL339687 | 0.63 | THRA (0.49) | SMN1; SMN2MEN1KMT2ALMNATHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |