Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GMNN | O75496 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23969316 | 0.88 | MTNR1A (0.37) | MTNR1AMAPK1KDM4ELMNA | |
| SCHEMBL22175873 | 0.86 | — | — | |
| SCHEMBL22175925 | 0.83 | MEN1 (0.36) | MTNR1AMAPTTP53CYP1A2ALOX15 | |
| SCHEMBL22175847 | 0.81 | SIGMAR1 (0.40) | MTNR1AMAPTTP53CYP1A2ALOX15 | |
| SCHEMBL22176515 | 0.79 | MTNR1A (0.35) | MTNR1AMAPTTP53CYP1A2ALOX15 | |
| SCHEMBL22175868 | 0.75 | GABRG2 (0.31) | TSHRHSD17B10ALDH1A1HPGD | |
| SCHEMBL22176065 | 0.74 | HPGD (0.33) | MTNR1AALDH1A1HPGD | |
| SCHEMBL22175843 | 0.74 | THRB (0.42) | ALOX15TSHRNFKB1ALDH1A1LMNA | |
| SCHEMBL23969189 | 0.74 | MEN1 (0.36) | MTNR1ATSHRHSD17B10KDM4EALDH1A1 | |
| SCHEMBL23969380 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3903788-A1 | PYRAZOLO[1,5-A]PYRIMIDINE MACROCYCLIC COMPOUND | Taisho Pharmaceutical Co., Ltd. (JP) | 2021-11-03 | — | — | EP | disclosed |