Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.47 |
| ▸ | PTGER3 | P43115 | 3/20 | 0.47 |
| ▸ | PTGER2 | P43116 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CTSG | P08311 | 1/20 | 0.44 |
| ▸ | CMA1 | P23946 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6112808 | 0.89 | PPARA (0.51) | LMNAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL11111891 | 0.85 | POLB (0.50) | LMNAPOLBFFAR1NPSR1SMN1; SMN2 | |
| SCHEMBL11198865 | 0.83 | CXCL8 (0.53) | LMNAPOLBCA12CA1CA2 | |
| SCHEMBL362209 | 0.83 | LMNA (0.59) | LMNAPOLBFFAR1NPSR1SMN1; SMN2 | |
| SCHEMBL29590071 | 0.83 | LMNA (0.59) | LMNAPOLBFFAR1NPSR1SMN1; SMN2 | |
| SCHEMBL490691 | 0.82 | CTSG (0.56) | LMNAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL3691207 | 0.82 | ALOX5 (0.59) | LMNAPOLBFFAR1CA12CA1 | |
| SCHEMBL3954801 | 0.82 | LMNA (0.50) | LMNAPTGER1PTGER4PTGER3PTGER2 | |
| SCHEMBL27330479 | 0.82 | CYP4F2 (0.56) | POLBPPARASMN1; SMN2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL7413528 | 0.81 | LMNA (0.57) | LMNAPOLBFFAR1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2542549-B1 | INHIBITORS OF GLUTAMINYL CYCLASE | PROBIODRUG AG (DE) | 2016-05-11 | — | — | EP | disclosed |
| US-9181233-B2 | Inhibitors of glutaminyl cyclase | PROBIODRUG AG (DE) | 2015-11-10 | — | — | US | disclosed |
| EP-2542549-A2 | INHIBITORS OF GLUTAMINYL CYCLASE | Probiodrug AG (DE) | 2013-01-09 | — | — | EP | disclosed |
| US-20110224259-A1 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-15 | — | — | US | disclosed |
| WO-2011107530-A2 | NOVEL INHIBITORS | PROBIODRUG AG (DE) | 2011-09-09 | — | — | WO | disclosed |
| CN-1044652-A | Pyrrolidine compound and its pharmaceutical use | EISAI CO LTD (JP) | 1990-08-15 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110224259-A1 | NOVEL INHIBITORS | QPCT, GLUL, GLS | LMNA 3165/4885PTGER1 3108/4885PTGER4 3487/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.