SCHEMBL23972607

SCHEMBL23972607

COc1cc(OCOc2cc(O)c(Cl)cc2F)c(F)cc1Cl

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.40
FLT1 P17948 3/20 0.38
KDR P35968 3/20 0.38
FGFR1 P11362 2/20 0.38
FGFR2 P21802 1/20 0.38
FGFR4 P22455 1/20 0.38
FGFR3 P22607 1/20 0.38
FLT4 P35916 1/20 0.38
TAAR1 Q96RJ0 1/20 0.38
ALDH1A1 P00352 2/20 0.37
KDM4E B2RXH2 2/20 0.37
KMT2A Q03164 1/20 0.37
RAF1 P04049 1/20 0.37
BRAF P15056 1/20 0.37
HMGCR P04035 1/20 0.37
NPC1 O15118 2/20 0.36
FTO Q9C0B1 1/20 0.36
DPP4 P27487 1/20 0.36
MAPT P10636 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21611906 0.83 HMGCR (0.41) FLT1KDRFGFR1FGFR2FGFR4
SCHEMBL21614370 0.79 NPC1 (0.45) GAATAAR1ALDH1A1KDM4EKMT2A
SCHEMBL32675249 0.79 NPC1 (0.45) GAATAAR1ALDH1A1KDM4EKMT2A
SCHEMBL7792597 0.77 NPC1 (0.56) GAAKDRTAAR1NPC1FTO
SCHEMBL11548272 0.73 TSHR (0.52) GAATAAR1ALDH1A1KDM4EKMT2A
SCHEMBL6739489 0.71 TAAR1 (0.51) GAATAAR1NPC1MAPTRAB9A
SCHEMBL11003488 0.71 HTT (0.48) KDRHMGCRDPP4
SCHEMBL4398163 0.69 GAA (0.56) GAATAAR1ALDH1A1KDM4EKMT2A
SCHEMBL69147 0.69 HSD17B10 (0.52) ALDH1A1KDM4EKMT2AFTODPP4
SCHEMBL3611033 0.68 LMNA (0.39) ALDH1A1KDM4EKMT2AHMGCRMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210337789-A1 Derivatives of m-Guaiacol, Their Preparation and Their Uses UNIVERSITE DE CAEN NORMANDIE (FR) 2021-11-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210337789-A1 Derivatives of m-Guaiacol, Their Preparation and Their Uses MPG, MGLL, GANC GAA 234/4885FLT1 4809/4885KDR 4763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.