Sugi Predict

Sugi Predict / Compounds / SCHEMBL2397361

SCHEMBL2397361

SCHEMBL2397361

O=C(O)c1cc(C(F)(F)F)ncc1Cl

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ ASPH Q12797 2/20 0.45
▸ SORT1 Q99523 1/20 0.41
▸ SYK P43405 2/20 0.41
▸ ALDH1A1 P00352 1/20 0.40
▸ TP53 P04637 1/20 0.40
▸ MRGPRX4 Q96LA9 1/20 0.39
▸ SMARCA2 P51531 1/20 0.38
▸ SMARCA4 P51532 1/20 0.38
▸ GLA P06280 1/20 0.38
▸ HPGD P15428 1/20 0.38
▸ LMNA P02545 1/20 0.38
▸ P2RX7 Q99572 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.37
▸ KDM8 Q8N371 1/20 0.37
▸ KEAP1 Q14145 1/20 0.37
▸ NFE2L2 Q16236 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30064462 1.00 ASPH (0.45) ASPHSORT1SYKALDH1A1TP53
SCHEMBL29754010 0.87 ASPH (0.46) ASPHSORT1SYKSMARCA2SMARCA4
SCHEMBL14921073 0.87 ASPH (0.46) ASPHSORT1SYKSMARCA2SMARCA4
SCHEMBL22542503 0.86 SMARCA2 (0.38) ASPHALDH1A1SMARCA2SMARCA4GLA
SCHEMBL22542502 0.84 CASP1 (0.42) ALDH1A1SMARCA2SMARCA4
SCHEMBL28678200 0.83 SYK (0.33) ASPHSORT1SYKP2RX7
SCHEMBL29455012 0.83 SYK (0.33) ASPHSORT1SYKP2RX7
SCHEMBL24391437 0.80 MAPT (0.47) ALDH1A1MRGPRX4LMNA
SCHEMBL31561427 0.80 MAPT (0.47) ALDH1A1MRGPRX4LMNA
SCHEMBL2394618 0.80 ASPH (0.59) ASPHKDM4EKDM8KEAP1NFE2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12538924-B2 Pesticidally active heterocyclic derivatives with sulfur containing substituents SYNGENTA CROP PROTECTION AG (CH) 2026-02-03 — — US disclosed
CN-113811532-B Pesticidally active heterocyclic derivatives with sulfur containing substituents 先正达农作物保护股份公司 2025-04-11 — — CN disclosed
CN-115023426-B Pesticidally active heterocyclic derivatives with sulfur containing substituents 先正达农作物保护股份公司 2024-11-12 — — CN disclosed
EP-4400172-A2 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS Incyte Holdings Corporation (US) 2024-07-17 — — EP disclosed
US-20240174696-A1 2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS GENENTECH, INC. (US) 2024-05-30 — — US disclosed
EP-4036088-B1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE HOLDINGS CORP (US) 2024-04-03 — — EP disclosed
CN-117425654-A 2, 8-diazaspiro [4.5] decane compounds 基因泰克公司 2024-01-19 — — CN disclosed
EP-3931194-B1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2023-12-06 — — EP disclosed
US-20230348496-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2023-11-02 — — US disclosed
US-20230348496-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS SYNGENTA CROP PROTECTION AG (CH) 2023-11-02 — — US disclosed
US-9464088-B2 Piperidin-4-yl azetidine derivatives as JAK1 inhibitors INCYTE HOLDINGS CORPORATION (US) 2016-10-11 — — US disclosed
EP-3050882-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS Incyte Holdings Corporation (US) 2016-08-03 — — EP disclosed
US-20160130278-A1 GLYCINE TRANSPORTER INHIBITOR TAISHO PHARMACEUTICAL CO., LTD (JP) 2016-05-12 — — US disclosed
EP-3009421-A1 GLYCINE TRANSPORTER INHIBITOR Taisho Pharmaceutical Co., Ltd. (JP) 2016-04-20 — — EP disclosed
EP-2545045-B1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE HOLDINGS CORP (US) 2016-01-06 — — EP disclosed
US-20140275031-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE CORPORATION (US) 2014-09-18 — — US disclosed
US-8765734-B2 Piperidin-4-yl azetidine derivatives as JAK1 inhibitors INCYTE CORPORATION (US) 2014-07-01 — — US disclosed
EP-2545045-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS Incyte Corporation (US) 2013-01-16 — — EP disclosed
US-20110224190-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE CORPORATION 2011-09-15 — — US disclosed
WO-2011112662-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS INCYTE CORPORATION (US) 2011-09-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12538924-B2 Pesticidally active heterocyclic derivatives with sulfur containing substituents CBR3, CBR1, CYCS ASPH 1982/4885SORT1 4859/4885SYK 4202/4885
US-20240174696-A1 2,8-DIAZASPIRO[4.5]DECANE COMPOUNDS LATS1, LATS2, GLS2 ASPH 2673/4885SORT1 3528/4885SYK 4714/4885
US-20140275031-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS JAK1, JAK2, JAK3 ASPH 3087/4885SORT1 4366/4885SYK 71/4885
US-20230348496-A1 PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULFUR CONTAINING SUBSTITUENTS FOXM1, GLRX3, ACHE ASPH 1809/4885SORT1 4425/4885SYK 2980/4885
US-20110224190-A1 PIPERIDIN-4-YL AZETIDINE DERIVATIVES AS JAK1 INHIBITORS JAK1, JAK2, JAK3 ASPH 3087/4885SORT1 4366/4885SYK 71/4885
US-20160130278-A1 GLYCINE TRANSPORTER INHIBITOR SLC1A2, SLC6A5, SLC18A2 ASPH 443/4885SORT1 1030/4885SYK 2280/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.