Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.54 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | DGAT2 | Q96PD7 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30558743 | 1.00 | ALDH1A1 (0.57) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL30856388 | 0.84 | KDM1A (0.53) | ALDH1A1PKMHPGDTP53MAPT | |
| SCHEMBL30856041 | 0.81 | DGAT2 (0.61) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL17710988 | 0.78 | TAS1R3 (0.56) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL2856684 | 0.78 | TAS1R3 (0.58) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL24914439 | 0.78 | TAS1R3 (0.66) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL17027175 | 0.77 | LMNA (0.53) | ALDH1A1HPGDHTTLMNAMAOB | |
| SCHEMBL23985899 | 0.77 | TAS1R3 (0.71) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL30305533 | 0.77 | TAS1R3 (0.71) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 | |
| SCHEMBL29147551 | 0.77 | TAS1R3 (0.71) | ALDH1A1TSHRNPSR1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250171444-A1 | PI3Ka INHIBITORS | PIKAVATION THERAPEUTICS, INC. | 2025-05-29 | — | — | US | disclosed |
| US-20230353959-A1 | PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-11-02 | — | — | US | disclosed |
| US-20230353959-A1 | PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. | 2023-11-02 | — | — | US | disclosed |
| WO-2023168378-A1 | PI3KA INHIBITORS | SYNNOVATION THERAPEUTICS, INC. (US) | 2023-09-07 | — | — | WO | disclosed |
| WO-2023168378-A1 | PI3KA INHIBITORS | SYNNOVATION THERAPEUTICS, INC. (US) | 2023-09-07 | — | — | WO | disclosed |
| WO-2021222556-A1 | PI3K-α INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250171444-A1 | PI3Ka INHIBITORS | PIK3CA, PIK3C2A, PIK3R5 | ALDH1A1 3204/4885TSHR 2472/4885NPSR1 4804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.