Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27573306 | 0.87 | THRB (0.38) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL27586458 | 0.84 | THRB (0.36) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL1888853 | 0.75 | THRB (0.38) | THRBTSHRALDH1A1 | |
| SCHEMBL11106079 | 0.73 | ALDH1A1 (0.35) | THRBTSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL2398902 | 0.73 | THRB (0.38) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL302801 | 0.72 | THRB (0.43) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL1108008 | 0.72 | TSHR (0.43) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL20838806 | 0.71 | TSHR (0.33) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| Ammonia Solution, Strong SCHEMBL6720468 | 0.71 | TSHR (0.42) | THRBTSHRHPGDALDH1A1CYP3A4 | |
| SCHEMBL865173 | 0.71 | THRB (0.42) | THRBTSHRHPGDALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8013162-B2 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION (US) | 2011-09-06 | — | — | US | disclosed |
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | CIBA CORPORATION | 2009-08-13 | — | — | US | disclosed |
| WO-2005092992-A1 | INK JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2005-10-06 | — | — | WO | disclosed |
| WO-2002055617-A1 | INK-JET INK AND RECORDING MATERIAL | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2002-07-18 | — | — | WO | disclosed |
| EP-0425429-A2 | Light stabilised inks | CIBA-GEIGY AG (CH) | 1991-05-02 | — | — | EP | disclosed |
| EP-0415880-A2 | Light stabilised inks | CIBA-GEIGY AG (CH) | 1991-03-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090202725-A1 | Water compatible sterically hindered alkoxyamines and hydroxy substituted alkoxyamines | AAAS, IWS1, HTR7 | THRB 4499/4885TSHR 4341/4885HPGD 1560/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.