Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GHSR | Q92847 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | F13A1 | P00488 | 1/20 | 0.48 |
| ▸ | TGM1 | P22735 | 1/20 | 0.48 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.47 |
| ▸ | BRD1 | O95696 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20885056 | 0.87 | TGM2 (0.63) | TGM2LMNAALDH1A1MAPTPKM | |
| SCHEMBL23988635 | 0.87 | BTK (0.52) | TGM2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL1381808 | 0.85 | TGM2 (0.65) | TGM2LMNASMN1; SMN2CA12CA1 | |
| SCHEMBL23988607 | 0.85 | PGR (0.54) | TGM2ALDH1A1MAPTPKMPOLB | |
| SCHEMBL3821674 | 0.85 | ALDH1A1 (0.71) | TGM2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14394819 | 0.85 | CES1 (0.65) | TGM2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9568792 | 0.85 | ALDH1A1 (0.71) | TGM2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3820009 | 0.83 | TGM2 (0.67) | TGM2SMN1; SMN2ALDH1A1PKMPOLB | |
| SCHEMBL14394824 | 0.82 | ALDH1A1 (0.65) | TGM2LMNASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL9568604 | 0.81 | TGM2 (0.64) | TGM2ALDH1A1PKMPOLBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-10-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11155556-B2 | Pyrimido-diazepinone kinase scaffold compounds and methods for treating PI3K-mediated disorders | PI4KA, PIK3CA, PI4KB | TGM2 2619/4885LMNA 2983/4885SMN1; SMN2 1752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.