SCHEMBL2401113

SCHEMBL2401113

CC(C)[Si](OCO)(C(C)C)C(C)C

nearest known ligand 0.32

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2655908 0.77 ALDH1A1 (0.33) TSHR
SCHEMBL2255020 0.73
SCHEMBL550380 0.71 LMNA (0.35)
SCHEMBL22470938 0.71 SMN1; SMN2 (0.32) TSHR
SCHEMBL839621 0.71 MAPK1 (0.40) TSHRTDP1
SCHEMBL7111444 0.71
SCHEMBL839620 0.71 MAPK1 (0.40) TSHRTDP1
SCHEMBL3291638 0.71
SCHEMBL840510 0.71 MAPK1 (0.40) TSHRTDP1
SCHEMBL22471035 0.69 LMNA (0.35) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1483280-B1 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RES CORP (US) 2012-10-24 EP claimed
EP-1483280-A4 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RES CORP (US) 2007-05-02 EP claimed
US-7144995-B2 Fluorescent nitrogenous base and nucleosides incorporating same GLEN RESEARCH CORPORATION (US) 2006-12-05 US claimed
EP-1483280-A2 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME Glen Research Corporation (US) 2004-12-08 EP claimed
US-20040009933-A1 Fluorescent nitrogenous base and nucleosides incorporating same GLEN RESEARCH CORPORATION (US) 2004-01-15 US claimed
WO-2003077215-A2 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RESEARCH CORPORATION (US) 2003-09-18 WO claimed
US-20170253911-A1 Methods for Enriching for a Population of RNA Molecules NEW ENGLAND BIOLABS, INC. (US) 2017-09-07 US disclosed
EP-1483280-B1 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RES CORP (US) 2012-10-24 EP disclosed
US-8026349-B2 Polynucleotide synthesis labeling chemistry DHARMACON, INC. (US) 2011-09-27 US disclosed
WO-2010025566-A1 RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) 2010-03-11 WO disclosed
US-20080009612-A1 Novel Polynucleotide Synthesis Labeling Chemistry DHARMACON, INC. 2008-01-10 US disclosed
EP-1788875-A2 NOVEL POLYNUCLEOTIDE SYNTHESIS LABELING CHEMISTRY Dharmacon, Inc. (US) 2007-05-30 EP disclosed
EP-1483280-A4 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RES CORP (US) 2007-05-02 EP disclosed
US-7144995-B2 Fluorescent nitrogenous base and nucleosides incorporating same GLEN RESEARCH CORPORATION (US) 2006-12-05 US disclosed
US-20060167241-A1 Method for synthesizing cyclic bisdinucleoside MITSUI CHEMICALS, INC. (JP) 2006-07-27 US disclosed
EP-1645561-A1 METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE Mitsui Chemicals, Inc. (JP) 2006-04-12 EP disclosed
WO-2006033730-A2 NOVEL POLYNUCLEOTIDE SYNTHESIS LABELING CHEMISTRY DHARMACON, INC. (US) 2006-03-30 WO disclosed
EP-1483280-A2 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME Glen Research Corporation (US) 2004-12-08 EP disclosed
US-20040009933-A1 Fluorescent nitrogenous base and nucleosides incorporating same GLEN RESEARCH CORPORATION (US) 2004-01-15 US disclosed
WO-2003077215-A2 FLUORESCENT NITROGENOUS BASE AND NUCLEOSIDES INCORPORATING SAME GLEN RESEARCH CORPORATION (US) 2003-09-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080009612-A1 Novel Polynucleotide Synthesis Labeling Chemistry POLN, POLRMT, POLM TSHR 4134/4885TDP1 123/4885
US-20040009933-A1 Fluorescent nitrogenous base and nucleosides incorporating same NUDT1, NT5C3B, NCL TSHR 4178/4885TDP1 216/4885
US-20060167241-A1 Method for synthesizing cyclic bisdinucleoside NSUN2, POLR2H, POLB TSHR 1768/4885TDP1 573/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.