Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAB2 | O43741 | 5/20 | 0.56 |
| ▸ | PRKAG1 | P54619 | 5/20 | 0.56 |
| ▸ | PRKAA2 | P54646 | 5/20 | 0.56 |
| ▸ | PRKAA1 | Q13131 | 5/20 | 0.56 |
| ▸ | PRKAG3 | Q9UGI9 | 5/20 | 0.56 |
| ▸ | PRKAG2 | Q9UGJ0 | 5/20 | 0.56 |
| ▸ | PRKAB1 | Q9Y478 | 5/20 | 0.56 |
| ▸ | USP2 | O75604 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NOS1 | P29475 | 1/20 | 0.55 |
| ▸ | NOS2 | P35228 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24011606 | 0.83 | PRKAB2 (0.61) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL24011319 | 0.82 | POLB (0.43) | SMN1; SMN2GRM3POLBALDH1A1HPGD | |
| SCHEMBL24011556 | 0.78 | ACHE (0.49) | SMN1; SMN2NOS1NOS2MEN1KMT2A | |
| SCHEMBL24011323 | 0.78 | HRH1 (0.47) | PRKAB2PRKAG1PRKAA2PRKAA1PRKAG3 | |
| SCHEMBL13826413 | 0.75 | EPHX2 (0.62) | PRKAA2NOS1NOS2POLBALDH1A1 | |
| SCHEMBL24011391 | 0.74 | ALDH1A1 (0.48) | TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL24011481 | 0.74 | NPC1 (0.68) | SMN1; SMN2GRM3MEN1KMT2APOLB | |
| SCHEMBL18657677 | 0.74 | ALDH1A1 (0.63) | SMN1; SMN2GRM3MEN1KMT2APOLB | |
| SCHEMBL13826658 | 0.74 | HPGD (0.66) | TSHRSMN1; SMN2GRM3KMT2APOLB | |
| SCHEMBL16003042 | 0.73 | EPHX2 (0.62) | PRKAA2NOS1NOS2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021226276-A2 | NAMPT MODULATORS | CYTOKINETICS, INC. (US) | 2021-11-11 | — | — | WO | disclosed |