SCHEMBL2403333

SCHEMBL2403333

CC(=O)Cn1c(=O)sc2cc(Br)ccc21

nearest known ligand 0.50

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 5/20 0.50
CDYL2 Q8N8U2 3/20 0.43
CDYL Q9Y232 3/20 0.43
CUL4A Q13619 1/20 0.43
GAA P10253 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
POLB P06746 2/20 0.40
MAPT P10636 2/20 0.40
MEN1 O00255 1/20 0.40
ALDH1A1 P00352 1/20 0.40
KMT2A Q03164 1/20 0.40
CBX7 O95931 1/20 0.40
CDY1; CDY1B Q9Y6F8 1/20 0.40
TSHR P16473 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
RXFP1 Q9HBX9 1/20 0.39
CNR2 P34972 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2407440 0.85 SIGMAR1 (0.50) SIGMAR1CDYL2CDYLGAASMN1; SMN2
SCHEMBL28909421 0.81 SIGMAR1 (0.54) SIGMAR1SMN1; SMN2MAPT
SCHEMBL3043755 0.81 SIGMAR1 (0.54) SIGMAR1CDYL2CDYLPOLBMAPT
SCHEMBL2073651 0.79 SIGMAR1 (0.59) SIGMAR1MAPTCNR2
SCHEMBL14681114 0.79 SIGMAR1 (0.59) SIGMAR1MAPTCNR2
SCHEMBL17288108 0.78 SIGMAR1 (0.51) SIGMAR1GAASMN1; SMN2POLBMAPT
SCHEMBL7716707 0.78 SIGMAR1 (0.51) SIGMAR1
SCHEMBL30612637 0.78 GAA (0.57) SIGMAR1GAASMN1; SMN2POLBMAPT
SCHEMBL7712083 0.77 SIGMAR1 (0.63) SIGMAR1CNR2
SCHEMBL5416113 0.75 SIGMAR1 (0.50) SIGMAR1GAASMN1; SMN2MEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230277501-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2023-09-07 US disclosed
US-20230033195-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2023-02-02 US disclosed
US-20220265685-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2022-08-25 US disclosed
US-11160785-B2 Methods and compositions for improving cognitive function AGENEBIO INC. (US) 2021-11-02 US disclosed
US-20210244709-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2021-08-12 US disclosed
EP-3827820-A1 BRIVARACETAM FOR IMPROVING COGNITIVE FUNCTION The Johns Hopkins University (US) 2021-06-02 EP disclosed
US-10806717-B2 Methods and compositions for improving cognitive function THE JOHNS HOPKINS UNIVERSITY (US) 2020-10-20 US disclosed
US-10624875-B2 Methods and compositions for treating schizophrenia THE JOHNS HOPKINS UNIVERSITY (US) 2020-04-21 US disclosed
EP-3610890-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA The Johns Hopkins University (US) 2020-02-19 EP disclosed
US-10154988-B2 Methods and compositions for treating schizophrenia THE JOHNS HOPKINS UNIVERSITY (US) 2018-12-18 US disclosed
US-20150313876-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA THE JOHNS HOPKINS UNIVERSITY 2015-11-05 US disclosed
WO-2014144546-A1 METHODS AND COMPOSITONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2014-09-18 WO disclosed
WO-2014144801-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION AGENEBIO INC. (US) 2014-09-18 WO disclosed
US-20140206667-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA THE JOHNS HOPKINS UNIVERSITY 2014-07-24 US disclosed
US-20120214859-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY 2012-08-23 US disclosed
US-20110212928-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION THE JOHNS HOPKINS UNIVERSITY (US) 2011-09-01 US disclosed
US-20100222326-A1 New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders UCB PHARMA, S.A. (BE) 2010-09-02 US disclosed
EP-2152262-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB Pharma, S.A. (BE) 2010-02-17 EP disclosed
WO-2008132139-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB PHARMA S.A. (BE) 2008-11-06 WO disclosed
WO-2008132142-A2 NEW HETEROCYCLIC DERIVATIVES USEFUL FOR THE TREATMENT OF CNS DISORDERS UCB PHARMA S.A. (BE) 2008-11-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10806717-B2 Methods and compositions for improving cognitive function GRIN2A, CHRNA2, SYNGR2 SIGMAR1 2765/4885CDYL2 339/4885CDYL 1611/4885
US-20150313876-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA RAB2A, SYNGR2, GRIN2A SIGMAR1 2281/4885CDYL2 971/4885CDYL 2385/4885
US-10154988-B2 Methods and compositions for treating schizophrenia RAB2A, SYNGR2, GRIN2A SIGMAR1 2281/4885CDYL2 971/4885CDYL 2385/4885
US-20210244709-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, CHRNA2, SYNGR2 SIGMAR1 2765/4885CDYL2 339/4885CDYL 1611/4885
US-11160785-B2 Methods and compositions for improving cognitive function BACE2, BACE1, GRIN2A SIGMAR1 2391/4885CDYL2 1832/4885CDYL 3482/4885
US-10624875-B2 Methods and compositions for treating schizophrenia RAB2A, SYNGR2, GRIN2A SIGMAR1 2258/4885CDYL2 478/4885CDYL 1285/4885
US-20140206667-A1 METHODS AND COMPOSITIONS FOR TREATING SCHIZOPHRENIA RAB2A, SYNGR2, GRIN2A SIGMAR1 2258/4885CDYL2 478/4885CDYL 1285/4885
US-20100222326-A1 New Heterocyclic Derivatives Useful For The Treatment of CNS Disorders CNR2, CNR1, SLC18A2 SIGMAR1 263/4885CDYL2 2678/4885CDYL 2832/4885
US-20120214859-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, GRIN2D, SLC18A2 SIGMAR1 3738/4885CDYL2 2505/4885CDYL 4453/4885
US-20230277501-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2A, CHRNA2, SYNGR2 SIGMAR1 2765/4885CDYL2 339/4885CDYL 1611/4885
US-20220265685-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION BACE1, BACE2, ACHE SIGMAR1 3684/4885CDYL2 3071/4885CDYL 4362/4885
US-20110212928-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION BACE1, BACE2, ACHE SIGMAR1 3684/4885CDYL2 3071/4885CDYL 4362/4885
US-20230033195-A1 METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION GRIN2D, GRIN2A, SLC18A2 SIGMAR1 3707/4885CDYL2 2361/4885CDYL 4273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.