Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.59 |
| ▸ | RAB9A | P51151 | 5/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
| ▸ | CDK8 | P49336 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28663512 | 0.86 | ALDH1A1 (0.69) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL1568786 | 0.79 | PABPC1 (0.65) | ALDH1A1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL6630687 | 0.76 | HSP90AA1 (0.56) | ALDH1A1RAB9AKMT2AMEN1HSP90AA1 | |
| SCHEMBL5486894 | 0.75 | NPC1 (0.67) | ALDH1A1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL11132897 | 0.75 | KMT2A (0.82) | ALDH1A1KMT2AMEN1POLBMAPT | |
| SCHEMBL2403448 | 0.75 | KDM4E (0.72) | ALDH1A1NPC1RAB9ACASP3SENP8 | |
| SCHEMBL19924516 | 0.74 | ALDH1A1 (0.69) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL5267380 | 0.73 | ALDH1A1 (0.68) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2494747 | 0.72 | ALDH1A1 (0.72) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL15252796 | 0.72 | DGAT1 (0.60) | ALDH1A1NPC1RAB9ACASP3SENP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7655801-B2 | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2010-02-02 | — | — | US | claimed |
| EP-1831172-B1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2009-02-18 | — | — | EP | claimed |
| EP-1831172-A1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | Council of Scientific and Industrial Research (IN) | 2007-09-12 | — | — | EP | claimed |
| WO-2006070394-A1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-07-06 | — | — | WO | claimed |
| US-20060142335-A1 | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2006-06-29 | — | — | US | claimed |
| US-20220265685-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2022-08-25 | — | — | US | disclosed |
| US-11160785-B2 | Methods and compositions for improving cognitive function | AGENEBIO INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2018-01-18 | — | — | US | disclosed |
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | AGENEBIO, INC. | 2016-09-22 | — | — | US | disclosed |
| EP-2533645-B1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2016-07-27 | — | — | EP | disclosed |
| EP-2968220-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | Agenebio, Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| WO-2014144801-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | AGENEBIO INC. (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-01 | — | — | US | disclosed |
| US-7655801-B2 | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2010-02-02 | — | — | US | disclosed |
| EP-1831172-B1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | COUNCIL SCIENT IND RES (IN) | 2009-02-18 | — | — | EP | disclosed |
| EP-1831172-A1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | Council of Scientific and Industrial Research (IN) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006070394-A1 | SUBSTITUTED CARBAMIC ACID QUINOLIN-6-YL ESTERS USEFUL AS ACETYLCHOLINESTERASE INHIBITORS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2006-07-06 | — | — | WO | disclosed |
| US-20060142335-A1 | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2006-06-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160271108-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, BACE1, GRIN2A | ALDH1A1 1226/4885NPC1 1345/4885RAB9A 227/4885 |
| US-11160785-B2 | Methods and compositions for improving cognitive function | BACE2, BACE1, GRIN2A | ALDH1A1 1226/4885NPC1 1345/4885RAB9A 227/4885 |
| US-20180015109-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ALDH1A1 2614/4885NPC1 544/4885RAB9A 187/4885 |
| US-20060142335-A1 | Substituted carbamic acid quinolin-6-yl esters useful as acetylcholinesterase inhibitors | ACHE, BCHE, NAAA | ALDH1A1 885/4885NPC1 1934/4885RAB9A 935/4885 |
| US-20220265685-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ALDH1A1 2614/4885NPC1 544/4885RAB9A 187/4885 |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ALDH1A1 2614/4885NPC1 544/4885RAB9A 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.