SCHEMBL24045702

SCHEMBL24045702

O=C1C=CCCN1c1ccc(-c2ccccc2F)cc1

nearest known ligand 0.44

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.44
FPR2 P25090 2/20 0.42
DHODH Q02127 1/20 0.41
PTPRC P08575 1/20 0.39
PTPN1 P18031 1/20 0.39
GRM2 Q14416 1/20 0.37
ALDH1A1 P00352 1/20 0.36
MAPT P10636 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
DAO P14920 1/20 0.35
HRH3 Q9Y5N1 1/20 0.35
PAX8 Q06710 1/20 0.35
HSD11B1 P28845 1/20 0.35
CHRNA7 P36544 1/20 0.35
MCHR1 Q99705 3/20 0.35
CYP11B1 P15538 1/20 0.34
CYP11B2 P19099 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24045883 0.89 FPR2 (0.40) DGAT1FPR2DHODH
SCHEMBL24045707 0.83 DGAT1 (0.44) DGAT1MCHR1
SCHEMBL24045881 0.82 PTPRC (0.42) PTPRCPTPN1HRH3HSD11B1CYP11B1
SCHEMBL24045898 0.82 SLC6A7 (0.40) MCHR1
SCHEMBL24045791 0.81 CYP11B2 (0.38) DGAT1DHODHMAPTCYP11B1CYP11B2
SCHEMBL24045755 0.81 FPR1 (0.42) FPR2CYP11B2
SCHEMBL24045710 0.80 ESR2 (0.44) DGAT1FPR2MAPT
SCHEMBL24045767 0.80 FPR2 (0.42) FPR2L3MBTL1
SCHEMBL24045754 0.80 UGCG (0.46) FPR2PTPRCPTPN1GRM2ALDH1A1
SCHEMBL24045719 0.80 RAB9A (0.36) DGAT1ALDH1A1MAPTNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3414227-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-11-24 EP disclosed