SCHEMBL24045797

SCHEMBL24045797

CSNCc1cccc(-c2ccc(N3CCC=CC3=O)cc2)c1

nearest known ligand 0.34

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 3/20 0.34
CARM1 Q86X55 2/20 0.34
F10 P00742 1/20 0.34
LIPG Q9Y5X9 3/20 0.33
AOC3 Q16853 5/20 0.33
ROCK2 O75116 1/20 0.32
HTR5A P47898 1/20 0.31
BACE1 P56817 3/20 0.31
IDH1 O75874 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24045872 0.87 PRMT6 (0.34) PRMT6CARM1AOC3HTR5A
SCHEMBL24045806 0.86 MAP4K4 (0.34) AOC3ROCK2
SCHEMBL24045803 0.85 PRMT6 (0.34) PRMT6CARM1AOC3ROCK2BACE1
SCHEMBL24045813 0.83 PRMT6 (0.33) PRMT6CARM1F10LIPGAOC3
SCHEMBL24045954 0.81 POLB (0.33) F10ROCK2
SCHEMBL24045876 0.79 BACE1 (0.40) F10BACE1
SCHEMBL24045875 0.79 F10 (0.49) F10
SCHEMBL24045713 0.79 F10 (0.35) F10LIPG
SCHEMBL24045868 0.76 PTGS2 (0.44) F10AOC3BACE1
SCHEMBL24045892 0.74 TAAR1 (0.45) ROCK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3414227-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-11-24 EP disclosed