SCHEMBL24045872

SCHEMBL24045872

C=C1C=CCCN1c1ccc(-c2cccc(CNSC)c2)cc1

nearest known ligand 0.34

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 3/20 0.34
CARM1 Q86X55 2/20 0.34
HTR5A P47898 1/20 0.31
AOC3 Q16853 2/20 0.31
KDM1A O60341 1/20 0.30
MAOA P21397 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24045797 0.87 PRMT6 (0.34) PRMT6CARM1HTR5AAOC3
SCHEMBL24045803 0.74 PRMT6 (0.34) PRMT6CARM1AOC3
SCHEMBL24045875 0.74 F10 (0.49)
SCHEMBL24045806 0.73 MAP4K4 (0.34) AOC3
SCHEMBL24045813 0.70 PRMT6 (0.33) PRMT6CARM1HTR5AAOC3
SCHEMBL24045954 0.67 POLB (0.33)
SCHEMBL24045713 0.65 F10 (0.35)
SCHEMBL24045876 0.65 BACE1 (0.40)
SCHEMBL24045868 0.62 PTGS2 (0.44) AOC3
SCHEMBL24045892 0.60 TAAR1 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3414227-B1 PIPERIDINONE FORMYL PEPTIDE 2 RECEPTOR AND FORMYL PEPTIDE 1 RECEPTOR AGONISTS BRISTOL MYERS SQUIBB CO (US) 2021-11-24 EP disclosed