SCHEMBL2407614

SCHEMBL2407614

O=C(O)N(Cc1cscn1)CC1CCN(c2cccc(-c3cccc(OCC4CC4)c3)n2)CC1

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 4/20 0.42
FFAR1 O14842 2/20 0.40
CTSA P10619 1/20 0.39
DGAT1 O75907 7/20 0.37
CYP3A4 P08684 1/20 0.37
SOAT1 P35610 1/20 0.37
NR1H4 Q96RI1 1/20 0.37
LRRK2 Q5S007 1/20 0.36
CNR1 P21554 1/20 0.35
WDR5 P61964 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2406060 0.87 DKK1 (0.42) FFAR4DGAT1CNR1
SCHEMBL2408111 0.86 PRKD1 (0.37) FFAR4CNR1
SCHEMBL2405635 0.85 PIM2 (0.36) FFAR4FFAR1CNR1
SCHEMBL2406718 0.85 KMO (0.38) FFAR4CNR1
SCHEMBL2407113 0.85 SMN1; SMN2 (0.44) FFAR4CNR1WDR5
SCHEMBL2411477 0.85 CNR1 (0.40) CNR1WDR5
SCHEMBL2405723 0.84 FFAR4 (0.41) FFAR4FFAR1CTSACNR1
SCHEMBL2405902 0.84 FFAR4 (0.41) FFAR4CNR1
SCHEMBL2408149 0.84 FFAR1 (0.37) FFAR4FFAR1CTSADGAT1
SCHEMBL2408373 0.83 CNR1 (0.35) FFAR4CNR1WDR5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912218-B2 Alkylthiazol carbamate derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-12-16 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MET, ALK, REL FFAR4 677/4885FFAR1 391/4885CTSA 3601/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.