Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2512414 | 0.84 | ACHE (0.38) | MAPK14ALDH1A1TSHRACHELMNA | |
| SCHEMBL1259809 | 0.82 | TSHR (0.42) | MAPK14ALDH1A1TSHRACHEMEN1 | |
| SCHEMBL10066070 | 0.81 | ALDH1A1 (0.42) | ALDH1A1TSHRACHEMEN1KMT2A | |
| SCHEMBL1260047 | 0.78 | MAPK14 (0.40) | MAPK14ACHEKDM4EHSD17B10PDK1 | |
| SCHEMBL10081773 | 0.77 | KMO (0.47) | MAPK14ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL5214230 | 0.77 | MAPK14 (0.40) | MAPK14ALDH1A1SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL2985577 | 0.75 | CYP2A6 (0.41) | MAPK14ALDH1A1SLC22A2SLC22A1SLC22A3 | |
| SCHEMBL2975907 | 0.75 | CA1 (0.43) | MAPK14ALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL28231643 | 0.75 | CLK4 (0.41) | MAOBBRD4 | |
| SCHEMBL8136855 | 0.71 | HSD11B1 (0.38) | MAPK14ALDH1A1TSHRACHEKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539338-A1 | NOVEL MICROBICIDES | Syngenta Participations AG (CH) | 2013-01-02 | — | — | EP | disclosed |
| US-20120316184-A1 | NOVEL MICROBICIDES | SYNGENTA CROP PROTECTION LLC (US) | 2012-12-13 | — | — | US | disclosed |
| CN-102770433-A | Novel microbicides | SYNGENTA PARTICIPATIONS A G | 2012-11-07 | — | — | CN | disclosed |
| WO-2012069652-A2 | FUNGICIDE MIXTURES | SYNGENTA PARTICIPATIONS AG (CH) | 2012-05-31 | — | — | WO | disclosed |
| US-20120129875-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA CROP PROTECTION, LLC (US) | 2012-05-24 | — | — | US | disclosed |
| CN-102448954-A | Substituted quinazolines as fungicides | SYNGENTA PARTICIPATIONS AG | 2012-05-09 | — | — | CN | disclosed |
| WO-2011104183-A1 | NOVEL MICROBICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2011-09-01 | — | — | WO | disclosed |
| WO-2010136475-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2010-12-02 | — | — | WO | disclosed |
| CN-1989125-B | 2-(pyridin-2-yl)-pyrimidines and their use for controlling pathogenic fungi | BASF AG | 2010-12-01 | — | — | CN | disclosed |
| US-20100286175-A1 | 2-(Pyridin-2-yl)-pyrimidines and Their Use for Controlling Harmful Fungi | GRAMMENOS WASSILIOS | 2010-11-11 | — | — | US | disclosed |
| US-7786043-B2 | 2-(pyridin-2-yl)-pyrimidines and their use for controlling harmful fungi | BASF AKTIENGESELLSCHAFT (DE) | 2010-08-31 | — | — | US | disclosed |
| US-20080027085-A1 | 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi | BASF AKTIENGESELLSCHAFT (DE) | 2008-01-31 | — | — | US | disclosed |
| CN-1989125-A | 2-(pyridin-2-yl)-pyrimidines and their use for controlling pathogenic fungi | BASF AG (DE) | 2007-06-27 | — | — | CN | disclosed |
| US-6291472-B1 | 4a, 5a, 8a, 8b-tetrahydro-6H-pyrrolo[3′,4′:4, 5]furo[3,2-b] pyri-dine-6,8(7H)-dione derivatives for control of endoparasites processes for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-18 | — | — | US | disclosed |
| US-6110928-A | HUMAN OR VETERINARY MEDICINE | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080027085-A1 | 2-(Pyridin-2-Yl)-Pyrimidines and Their Use for Controlling Harmful Fungi | CBR1, CBR3, CNPY2 | MAPK14 2782/4885ALDH1A1 1007/4885SLC22A2 4203/4885 |
| US-20120129875-A1 | SUBSTITUTED QUINAZOLINES AS FUNGICIDES | NAT1, NQO2, NOX1 | MAPK14 386/4885ALDH1A1 1125/4885SLC22A2 2663/4885 |
| US-20100286175-A1 | 2-(Pyridin-2-yl)-pyrimidines and Their Use for Controlling Harmful Fungi | CBR1, CBR3, CNPY2 | MAPK14 2929/4885ALDH1A1 1029/4885SLC22A2 3937/4885 |
| US-20120316184-A1 | NOVEL MICROBICIDES | NOX1, MSR1, FPR1 | MAPK14 3770/4885ALDH1A1 116/4885SLC22A2 4566/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.