SCHEMBL2408758

SCHEMBL2408758

O=C(O)N(Cc1cscn1)CC1CCN(c2cccc(-c3ccc(C4CCCCC4)cc3)n2)CC1

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR4 Q5NUL3 8/20 0.36
DGAT1 O75907 1/20 0.36
DHODH Q02127 1/20 0.35
CKS1B P61024 1/20 0.34
SKP1 P63208 1/20 0.34
SKP2 Q13309 1/20 0.34
TRPA1 O75762 1/20 0.33
KDM6B O15054 1/20 0.33
CNR1 P21554 1/20 0.33
USP2 O75604 1/20 0.32
ALOX15 P16050 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
HSD17B10 Q99714 1/20 0.32
HSD11B1 P28845 1/20 0.32
AGTR2 P50052 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2411223 0.92 FFAR4 (0.36) FFAR4DGAT1DHODHCKS1BSKP1
SCHEMBL2405627 0.88 CNR1 (0.38) FFAR4DGAT1CNR1HSD11B1
SCHEMBL2404007 0.87 CPT2 (0.35) FFAR4DGAT1CKS1BSKP1SKP2
SCHEMBL2411477 0.86 CNR1 (0.40) CNR1SMN1; SMN2HSD17B10
SCHEMBL2406148 0.86 HSD11B1 (0.38) FFAR4CKS1BSKP1SKP2HSD11B1
SCHEMBL2406060 0.85 DKK1 (0.42) FFAR4DGAT1CNR1SMN1; SMN2AGTR2
SCHEMBL2411198 0.85 PIM1 (0.36) FFAR4CKS1BSKP1SKP2AGTR2
SCHEMBL2405641 0.85 FFAR4 (0.32) FFAR4CKS1BSKP1SKP2CNR1
SCHEMBL2405902 0.84 FFAR4 (0.41) FFAR4CNR1
SCHEMBL2408111 0.83 PRKD1 (0.37) FFAR4CKS1BSKP1SKP2CNR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8912218-B2 Alkylthiazol carbamate derivatives, preparation thereof and therapeutic use thereof SANOFI (FR) 2014-12-16 US disclosed
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF SANOFI-AVENTIS (FR) 2011-09-01 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110212963-A1 ALKYLTHIAZOL CARBAMATE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF MET, ALK, REL FFAR4 677/4885DGAT1 4017/4885DHODH 700/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.