Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.48 |
| ▸ | RXRB | P28702 | 1/20 | 0.48 |
| ▸ | RXRG | P48443 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 14/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24100344 | 0.88 | RXRA (0.55) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL24100149 | 0.80 | HPGD (0.47) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL24100196 | 0.80 | PLA2G7 (0.48) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL24099614 | 0.77 | AR (0.48) | RXRARXRBRXRGHPGDALDH1A1 | |
| SCHEMBL24099639 | 0.76 | HPGD (0.47) | HPGDALDH1A1LMNAHTTHSD17B10 | |
| SCHEMBL24099835 | 0.73 | HPGD (0.55) | HPGDALDH1A1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL24100898 | 0.72 | MGLL (0.37) | HPGDALDH1A1HSD17B10TLR8TLR7 | |
| SCHEMBL70806 | 0.69 | HPGD (0.79) | HPGDALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL24099852 | 0.68 | HPGD (0.47) | HPGDALDH1A1LMNAHTTHSD17B10 | |
| SCHEMBL3905925 | 0.68 | HPGD (0.83) | HPGDALDH1A1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3922247-A1 | 15-PGDH INHIBITOR | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-12-15 | — | — | EP | disclosed |