Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28709492 | 0.84 | LMNA (0.33) | DGAT1MAPT | |
| SCHEMBL28933724 | 0.81 | TSHR (0.36) | DGAT1MAPT | |
| SCHEMBL24118032 | 0.81 | NAALAD2 (0.39) | DGAT1MAPT | |
| SCHEMBL4961849 | 0.79 | MAPT (0.38) | MAPT | |
| SCHEMBL16837735 | 0.79 | ALDH1A1 (0.36) | DGAT1MAPT | |
| SCHEMBL27163495 | 0.79 | DGAT1 (0.35) | DGAT1MAPT | |
| SCHEMBL11740552 | 0.78 | MAPT (0.39) | DGAT1MAPT | |
| SCHEMBL11744854 | 0.74 | DGAT1 (0.32) | DGAT1MAPT | |
| SCHEMBL11743781 | 0.73 | MAPK1 (0.37) | DGAT1MAPT | |
| SCHEMBL18691994 | 0.73 | CTSK (0.32) | DGAT1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | MERCK SHARP & DOHME CORP. (US) | 2021-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210393600-A1 | Novel [1.1.1] Bicyclo Compounds as Indoleamine 2,3-Dioxygenase Inhibitors | IDO1, IDO2, TPH1 | DGAT1 1737/4885MAPT 1865/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.