Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LYPLA1 | O75608 | 1/20 | 0.52 |
| ▸ | LYPLA2 | O95372 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12266348 | 0.89 | ALDH1A1 (0.47) | LYPLA1LYPLA2SMN1; SMN2NPC1LMNA | |
| SCHEMBL12266314 | 0.87 | TSHR (0.45) | LYPLA1LYPLA2ABCB1HTR1ADRD2 | |
| SCHEMBL12266351 | 0.84 | SYK (0.50) | ABCB1HTR1ADRD2SMN1; SMN2NPC1 | |
| SCHEMBL1186729 | 0.80 | SMN1; SMN2 (0.49) | TSHRSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL1187407 | 0.80 | RAB9A (0.45) | ABCB1HTR1ADRD2SMN1; SMN2RAB9A | |
| SCHEMBL12314717 | 0.80 | PTPRA (0.40) | ABCB1HTR1ADRD2TSHRSMN1; SMN2 | |
| SCHEMBL9673277 | 0.79 | TSHR (0.60) | ABCB1HTR1ADRD2TSHRSMN1; SMN2 | |
| SCHEMBL12266424 | 0.78 | ABCB1 (0.40) | ABCB1HTR1ADRD2TSHRSMN1; SMN2 | |
| SCHEMBL13383673 | 0.78 | ENPP2 (0.43) | ABCB1HTR1ADRD2TSHRSMN1; SMN2 | |
| SCHEMBL12270615 | 0.78 | SYK (0.48) | TSHRLMNAALDH1A1SYKL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853424-B2 | Protein cross-linking inhibitor | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2014-10-07 | — | — | US | disclosed |
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212919-A1 | PROTEIN CROSS-LINKING INHIBITOR | BAZ2B, PRMT1, BRIX1 | LYPLA1 1153/4885LYPLA2 1988/4885ABCB1 2189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.