Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 10/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 10/20 | 0.40 |
| ▸ | PARP1 | P09874 | 4/20 | 0.40 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | NEK2 | P51955 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | NEK6 | Q9HC98 | 1/20 | 0.38 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30466416 | 1.00 | ACHE (0.43) | ACHEPARP10PARP11PARP1NUAK1 | |
| SCHEMBL24136596 | 0.86 | ACHE (0.39) | ACHEPARP10PARP11PARP1NUAK1 | |
| SCHEMBL30466436 | 0.86 | ACHE (0.39) | ACHEPARP10PARP11PARP1NUAK1 | |
| SCHEMBL24136595 | 0.86 | ACHE (0.39) | ACHEPARP10PARP11PARP1NUAK1 | |
| SCHEMBL24136727 | 0.76 | IMPDH2 (0.37) | ACHEPARP10PARP11PARP1CDC7 | |
| SCHEMBL30466437 | 0.75 | PARP10 (0.42) | ACHEPARP10PARP11PARP1CDC7 | |
| SCHEMBL24136591 | 0.75 | PARP10 (0.42) | ACHEPARP10PARP11PARP1CDC7 | |
| SCHEMBL31012419 | 0.72 | ACHE (0.54) | ACHEPARP10PARP11PARP1 | |
| SCHEMBL24136723 | 0.72 | ACHE (0.54) | ACHEPARP10PARP11PARP1 | |
| SCHEMBL19373850 | 0.71 | ACHE (0.32) | ACHENUAK1IGF1RMETPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116194108-B | Novel dioxoisoquinolinone derivatives and use thereof | 韩美药品株式会社 | 2025-05-30 | — | — | CN | disclosed |
| CN-113423710-B | Novel heterocyclic tricyclic derivative compounds and use thereof | 韩美药品株式会社 | 2024-06-14 | — | — | CN | disclosed |
| CN-116194108-A | Novel dioxoisoquinolinone derivatives and use thereof | 韩美药品株式会社 | 2023-05-30 | — | — | CN | disclosed |
| US-11535629-B2 | Dioxoloisoquinolinone derivatives and use thereof | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2022-12-27 | — | — | US | disclosed |
| US-20220135582-A1 | NOVEL HETEROTRICYCLIC DERIVATIVE COMPOUND AND USE OF SAME | HANMI PHARMACEUTICAL CO., LTD. (KR) | 2022-05-05 | — | — | US | disclosed |
| EP-3929199-A1 | NOVEL HETEROTRICYCLIC DERIVATIVE COMPOUND AND USE OF SAME | Hanmi Pharmaceutical Co., Ltd. (KR) | 2021-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11535629-B2 | Dioxoloisoquinolinone derivatives and use thereof | EZH2, EZH1, EED | ACHE 2606/4885PARP10 870/4885PARP11 1087/4885 |
| US-20220135582-A1 | NOVEL HETEROTRICYCLIC DERIVATIVE COMPOUND AND USE OF SAME | EZH2, EZH1, BMI1 | ACHE 4227/4885PARP10 499/4885PARP11 327/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.