Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.42 |
| ▸ | MTOR | P42345 | 4/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CCR4 | P51679 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.41 |
| ▸ | PI4KA | P42356 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13976075 | 0.83 | ACLY (0.53) | PIK3CGPIK3CAMTOR | |
| SCHEMBL13975447 | 0.83 | SLC40A1 (0.55) | PIK3CGPIK3CAMTOR | |
| SCHEMBL24139918 | 0.79 | TSHR (0.48) | PIK3CGPIK3CAMTORCCR4 | |
| SCHEMBL13975944 | 0.76 | CCR2 (0.52) | PIK3CACCR4 | |
| SCHEMBL24139747 | 0.76 | CYP2C9 (0.48) | PIK3CGPIK3CAMTORCCR4BRAF | |
| SCHEMBL24140017 | 0.76 | LMNA (0.51) | PIK3CACCR4 | |
| SCHEMBL19558829 | 0.75 | ACLY (0.51) | PIK3CGPIK3CAMTOR | |
| SCHEMBL24139709 | 0.74 | WDR5 (0.43) | PIK3CGPIK3CAMTORCCR4 | |
| SCHEMBL24139986 | 0.74 | KDM4E (0.48) | — | |
| SCHEMBL19286558 | 0.74 | PIK3CD (0.53) | PIK3CGPIK3CAPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2710018-B1 | MACROCYCLIC COMPOUNDS AS PROTEIN KINASE INHIBITORS | FUNDACION CENTRO NAC DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2021-12-29 | — | — | EP | disclosed |