Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 6/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | NFATC1 | O95644 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143557 | 0.88 | CYP19A1 (0.45) | NR1D1KDM4EMEN1MAPTHTT | |
| SCHEMBL24143548 | 0.88 | NFATC1 (0.50) | NR1D1NFATC1GSK3BDYRK1ASERPINE1 | |
| SCHEMBL24144502 | 0.85 | CYP19A1 (0.47) | NR1D1GSK3BKDM4EMEN1HTT | |
| SCHEMBL24143945 | 0.83 | NR1D1 (0.48) | NR1D1NFATC1GSK3BDYRK1APTK2 | |
| SCHEMBL24143944 | 0.81 | NR1D1 (0.69) | NR1D1 | |
| SCHEMBL24144070 | 0.81 | HTR6 (0.54) | NR1D1DYRK1ASERPINE1HTR6 | |
| SCHEMBL24142953 | 0.80 | CYP19A1 (0.47) | NR1D1SERPINE1HTR2AHTR6CHEK1 | |
| SCHEMBL24143743 | 0.80 | NR1D1 (0.50) | NR1D1HTR2AHTR6CHEK1 | |
| SCHEMBL24144465 | 0.78 | NR1D1 (0.48) | NR1D1HTR2AHTR6CHEK1 | |
| SCHEMBL24143664 | 0.77 | NR1D1 (0.44) | NR1D1HTR2ACAPN1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |