Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.47 |
| ▸ | NR1D1 | P20393 | 6/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.42 |
| ▸ | FNTB | P49356 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24143557 | 0.88 | CYP19A1 (0.45) | CYP19A1NR1D1TAAR1HTR6EGFR | |
| SCHEMBL24144070 | 0.85 | HTR6 (0.54) | CYP19A1NR1D1HTR6EGFRIGF1R | |
| SCHEMBL24144383 | 0.83 | CYP19A1 (0.49) | CYP19A1NR1D1FNTAFNTBTAAR1 | |
| SCHEMBL24143540 | 0.80 | NR1D1 (0.42) | NR1D1HTR6HTR2ASERPINE1CHEK1 | |
| SCHEMBL24143743 | 0.80 | NR1D1 (0.50) | CYP19A1NR1D1HTR6HTR2ACHEK1 | |
| SCHEMBL24142882 | 0.80 | HTR6 (0.44) | NR1D1HTR6EGFRIGF1RFLT4 | |
| SCHEMBL28811759 | 0.79 | HTR6 (0.59) | CYP19A1FNTAFNTBTAAR1HTR6 | |
| SCHEMBL24143548 | 0.79 | NFATC1 (0.50) | CYP19A1NR1D1HTR6EGFRIGF1R | |
| SCHEMBL24144386 | 0.78 | LMNA (0.45) | NR1D1TAAR1HTR6EGFRIGF1R | |
| SCHEMBL24144502 | 0.78 | CYP19A1 (0.47) | CYP19A1NR1D1TAAR1HTR6EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021263278-A1 | REV-ERB AGONISTS FOR THE TREATMENT OF TH17-MEDIATED INFLAMMATORY DISORDERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2021-12-30 | — | — | WO | disclosed |