Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | FCER2 | P06734 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24151529 | 0.91 | SYK (0.61) | SYKLMNAFCER2NTRK1NTRK3 | |
| SCHEMBL24151798 | 0.90 | SYK (0.44) | SYKTP53POLBNAMPTCYP19A1 | |
| SCHEMBL24152849 | 0.88 | MGAT2 (0.49) | SYKLMNAPOLBFCER2NTRK1 | |
| SCHEMBL24152858 | 0.87 | NTRK1 (0.46) | SYKNAMPTNTRK1CYP19A1KMT2A | |
| SCHEMBL24151530 | 0.86 | SYK (0.48) | SYKTP53FCER2NTRK1NTRK3 | |
| SCHEMBL24151508 | 0.85 | IDO1 (0.47) | SYKKMT2AALDH1A1MAPT | |
| SCHEMBL24152477 | 0.85 | SYK (0.49) | SYKLMNAPOLBKMT2AMEN1 | |
| SCHEMBL24151523 | 0.84 | SYK (0.42) | SYKLMNAPOLBFCER2NTRK1 | |
| SCHEMBL24152348 | 0.82 | SYK (0.47) | SYKPOLBFCER2 | |
| SCHEMBL24152577 | 0.81 | SCN3A (0.53) | SYKNAMPTNTRK1CYP19A1TLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021260722-A1 | DESIGN, SYNTHESIS OF NOVEL OXYINDOLE INHIBITORS OF DENV RNA DEPENDENT RNA POLYMERASE | TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE (IN) | 2021-12-30 | — | — | WO | disclosed |