Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLK2 | Q86UE8 | 7/20 | 0.46 |
| ▸ | RET | P07949 | 5/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24151529 | 0.82 | SYK (0.61) | TLK2SYKNTRK1NTRK2LMNA | |
| SCHEMBL24152390 | 0.80 | NTRK1 (0.45) | TLK2KDRNTRK1FGFR1FLT3 | |
| SCHEMBL14154383 | 0.78 | ALDH1A1 (0.57) | SYK | |
| SCHEMBL24152878 | 0.74 | MEN1 (0.39) | TLK2 | |
| SCHEMBL24151507 | 0.73 | SYK (0.53) | TLK2SYKNTRK1ROCK1NTRK2 | |
| SCHEMBL24152391 | 0.73 | FLT3 (0.41) | TLK2CDK2CCNE1NTRK1FLT3 | |
| SCHEMBL24152477 | 0.71 | SYK (0.49) | SYKCDK2LMNAPOLBMAPT | |
| SCHEMBL7812244 | 0.70 | LRRK2 (0.56) | RETRPS6KA3PDGFRBLRRK2PSEN1 | |
| SCHEMBL7812245 | 0.70 | LRRK2 (0.56) | RETRPS6KA3PDGFRBLRRK2PSEN1 | |
| SCHEMBL24152348 | 0.70 | SYK (0.47) | SYKCDK2KDRPOLBPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021260722-A1 | DESIGN, SYNTHESIS OF NOVEL OXYINDOLE INHIBITORS OF DENV RNA DEPENDENT RNA POLYMERASE | TRANSLATIONAL HEALTH SCIENCE AND TECHNOLOGY INSTITUTE (IN) | 2021-12-30 | — | — | WO | disclosed |