Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | ITGB1 | P05556 | 2/20 | 0.41 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.40 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12667380 | 0.86 | ALDH1A1 (0.46) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL20850576 | 0.80 | ALDH1A1 (0.47) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL9911525 | 0.80 | KMT2A (0.59) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL12674550 | 0.80 | KMT2A (0.55) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL16868406 | 0.78 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19SMN1; SMN2CHRM2 | |
| SCHEMBL21753375 | 0.78 | SLC6A2 (0.46) | ALDH1A1KMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL9559796 | 0.78 | ALDH1A1 (0.55) | ALDH1A1LMNACYP2C19SMN1; SMN2CHRM2 | |
| SCHEMBL21152902 | 0.77 | MAPT (0.46) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL3114984 | 0.77 | LOXL2 (0.58) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 | |
| SCHEMBL3271284 | 0.77 | SIGMAR1 (0.48) | ALDH1A1LMNACYP1A2ALOX15CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220033787-A1 | COMPOSITIONS AND METHODS FOR TREATING MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY | ENTRADA THERAPEUTICS, INC. | 2022-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220033787-A1 | COMPOSITIONS AND METHODS FOR TREATING MITOCHONDRIAL NEUROGASTROINTESTINAL ENCEPHALOPATHY | PYGB, FPGS, GLS2 | ALDH1A1 4516/4885LMNA 2959/4885CYP1A2 4126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.