Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 2/20 | 0.38 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MC4R | P32245 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26033099 | 0.85 | GRIN1 (0.42) | GRIN1GRIN2AGRIN2BOPRM1SLC6A2 | |
| SCHEMBL19869969 | 0.79 | ALDH1A1 (0.44) | GRIN1GRIN2AGRIN2BOPRM1SLC6A2 | |
| SCHEMBL10169480 | 0.75 | OPRD1 (0.47) | OPRM1HTR2AHTR2CSLC6A3OPRD1 | |
| SCHEMBL12925944 | 0.74 | OPRM1 (0.49) | GRIN1GRIN2AGRIN2BOPRM1KCNH2 | |
| SCHEMBL14279640 | 0.73 | SLC6A4 (0.56) | GRIN1GRIN2AGRIN2BOPRM1SLC6A2 | |
| SCHEMBL27598815 | 0.71 | CYP2D6 (0.47) | GRIN1GRIN2AGRIN2BOPRM1SLC6A2 | |
| SCHEMBL29964855 | 0.70 | LPL (0.41) | GRIN1GRIN2AGRIN2B | |
| SCHEMBL20899292 | 0.69 | GRIN1 (0.47) | GRIN1GRIN2AGRIN2BOPRM1SLC6A2 | |
| SCHEMBL4120887 | 0.69 | SLC6A9 (0.39) | GRIN1GRIN2AGRIN2BOPRM1HTR2A | |
| SCHEMBL101926 | 0.68 | ALDH1A1 (0.64) | SIGMAR1ALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | ARRAY BIOPHARMA INC (US) | 2022-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11247990-B1 | Bicyclic fused pyridine compounds as inhibitors of TAM kinases | MAP3K1, MAP3K3, MAP3K2 | GRIN1 1120/4885GRIN2A 1844/4885GRIN2B 1953/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.