Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | EED | O75530 | 1/20 | 0.48 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.48 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.48 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.48 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | STS | P08842 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2417525 | 0.84 | ALDH1A1 (0.50) | ALDH1A1MAPTHTTNPC1L3MBTL1 | |
| SCHEMBL1425292 | 0.83 | GPR119 (0.50) | ALDH1A1MAPTKDM4ETHRBPTPN2 | |
| SCHEMBL15028344 | 0.81 | PDE4B (0.50) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL7486842 | 0.81 | ALDH1A1 (0.60) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL2427750 | 0.81 | EED (0.56) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL25131450 | 0.81 | ALDH1A1 (0.46) | ALDH1A1MAPTHTTNPC1L3MBTL1 | |
| SCHEMBL2454067 | 0.80 | ALDH1A1 (0.43) | ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL2423692 | 0.80 | KDM4E (0.47) | ALDH1A1MAPTKDM4ETHRBPTPN2 | |
| SCHEMBL922043 | 0.78 | EED (0.53) | ALDH1A1EEDRBBP4SUZ12EZH2 | |
| SCHEMBL30736677 | 0.78 | EED (0.53) | ALDH1A1EEDRBBP4SUZ12EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2550252-B1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R & D IP LLC (US) | 2015-05-06 | — | — | EP | disclosed |
| EP-2550252-B1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R & D IP LLC (US) | 2015-05-06 | — | — | EP | disclosed |
| US-20130324550-A1 | 1-(2-PHENOXYMETHYLHETEROARYL) PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2013-12-05 | — | — | US | disclosed |
| US-8530663-B2 | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds | THERAVANCE, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530663-B2 | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds | THERAVANCE, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| US-8530663-B2 | 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds | THERAVANCE, INC. (US) | 2013-09-10 | — | — | US | disclosed |
| WO-2011119461-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE, INC. (US) | 2011-09-29 | — | — | WO | disclosed |
| US-20110230495-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-09-22 | — | — | US | disclosed |
| US-20110230495-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-09-22 | — | — | US | disclosed |
| US-20110230495-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | THERAVANCE BIOPHARMA R&D IP, LLC | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230495-A1 | 1-(2-PHENOXYMETHYLHETEROARYL)PIPERIDINE AND PIPERAZINE COMPOUNDS | HTR1A, HTR1D, HTR5A | ALDH1A1 223/4885EED 1916/4885RBBP4 3717/4885 |
| US-20130324550-A1 | 1-(2-PHENOXYMETHYLHETEROARYL) PIPERIDINE AND PIPERAZINE COMPOUNDS | HTR1A, HTR1D, HTR5A | ALDH1A1 223/4885EED 1916/4885RBBP4 3717/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.