Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.51 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 4/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.47 |
| ▸ | RIOK2 | Q9BVS4 | 5/20 | 0.47 |
| ▸ | GSK3A | P49840 | 3/20 | 0.47 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.47 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254507 | 0.86 | MEN1 (0.48) | L3MBTL1MEN1KMT2ALMNAGAA | |
| SCHEMBL24254519 | 0.77 | MGAT2 (0.57) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL9367263 | 0.75 | NR1H4 (0.83) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL24254550 | 0.72 | HPGD (0.46) | L3MBTL1MEN1KMT2ALMNAGAA | |
| SCHEMBL2038480 | 0.71 | L3MBTL1 (0.76) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL24254523 | 0.71 | HPGD (0.59) | L3MBTL1MEN1KMT2AMAPK10MAPK8 | |
| SCHEMBL13451637 | 0.71 | NR1H4 (0.74) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL28605599 | 0.70 | HCAR2 (0.70) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL13451638 | 0.68 | NR1H4 (0.74) | L3MBTL1MEN1KMT2ANR1H4NLRP3 | |
| SCHEMBL23135812 | 0.68 | KDM4E (0.58) | L3MBTL1MEN1KMT2AGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |