Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CLK1 | P49759 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24254550 | 0.86 | HPGD (0.46) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254521 | 0.86 | L3MBTL1 (0.52) | MEN1KMT2ALMNAMAPTL3MBTL1 | |
| SCHEMBL24254575 | 0.80 | MAPT (0.53) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254503 | 0.78 | MGAT2 (0.54) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254623 | 0.76 | KCNQ2 (0.53) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254494 | 0.74 | EPHX2 (0.55) | LMNAMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL24254499 | 0.73 | LMNA (0.53) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL26188045 | 0.73 | ALDH1A1 (0.57) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254502 | 0.70 | ALDH1A1 (0.66) | MEN1KMT2ALMNAMAPTHTT | |
| SCHEMBL24254523 | 0.70 | HPGD (0.59) | MEN1KMT2ALMNAMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022035804-A1 | SUBSTITUTED 3-AMINO-4-METHYLBENZENESULFONAMIDES AS SMALL MOLECULE INHIBITORS OF UBIQUITIN-SPECIFIC PROTEASE 28 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-02-17 | — | — | WO | disclosed |