Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.83 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.76 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.60 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.60 |
| ▸ | RIOK2 | Q9BVS4 | 4/20 | 0.57 |
| ▸ | GSK3A | P49840 | 2/20 | 0.57 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.57 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038480 | 0.92 | L3MBTL1 (0.76) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL11285414 | 0.89 | NLRP3 (0.74) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL13533414 | 0.89 | NR1H4 (0.76) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL28869815 | 0.88 | NR1H4 (0.79) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL13451637 | 0.88 | NR1H4 (0.74) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL13451638 | 0.88 | NR1H4 (0.74) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL14344626 | 0.85 | MEN1 (0.76) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL28869800 | 0.85 | NLRP3 (0.73) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL11275576 | 0.84 | KMT2A (0.67) | NR1H4NLRP3L3MBTL1MEN1KMT2A | |
| SCHEMBL28869801 | 0.84 | NR1H4 (0.69) | NR1H4NLRP3L3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0409163-B1 | Novel cyclic vinylogous N-hydroxy-N-methylureas useful as 5-lipoxygenase inhibitors | MERRELL DOW PHARMA (US) | 1994-12-21 | — | — | EP | disclosed |