Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.64 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 5/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.55 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13451637 | 0.88 | NR1H4 (0.74) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL9367263 | 0.88 | NR1H4 (0.83) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL13533414 | 0.87 | NR1H4 (0.76) | NR1H4L3MBTL1NLRP3MEN1KMT2A | |
| SCHEMBL28869822 | 0.86 | RAB9A (0.71) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL2038480 | 0.86 | L3MBTL1 (0.76) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL14344626 | 0.86 | MEN1 (0.76) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL28869815 | 0.85 | NR1H4 (0.79) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL28869814 | 0.85 | NR1H4 (0.73) | NR1H4L3MBTL1RIOK2NLRP3MEN1 | |
| SCHEMBL10163448 | 0.83 | EPHX2 (0.73) | MEN1KMT2ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL28869801 | 0.82 | NR1H4 (0.69) | NR1H4L3MBTL1NLRP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120264760-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| US-20100022547-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | BRANDEIS UNIVERSITY (US) | 2010-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120264760-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | IMPDH1, IMPDH2, ITPA | NR1H4 835/4885L3MBTL1 2751/4885RIOK2 1638/4885 |
| US-20100022547-A1 | Compounds and Methods for Treating Mammalian Gastrointestinal Parasitic Infections | IMPDH1, IMPDH2, ITPA | NR1H4 835/4885L3MBTL1 2751/4885RIOK2 1638/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.