Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | FDPS | P14324 | 2/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | RARB | P10826 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29269238 | 0.83 | CHRNB2 (0.37) | SMN1; SMN2FDPSFPR2LMNAMEN1 | |
| SCHEMBL5133385 | 0.83 | PDE4A (0.40) | SMN1; SMN2FDPSFPR2LMNATLR7 | |
| SCHEMBL1353073 | 0.79 | ALPG (0.41) | FDPSLMNATSHRMEN1KMT2A | |
| SCHEMBL28701458 | 0.79 | FDPS (0.39) | SMN1; SMN2FDPSESR1MEN1KMT2A | |
| Ethane SCHEMBL27625282 | 0.78 | ALPG (0.40) | FDPSLMNATSHRMEN1KMT2A | |
| SCHEMBL16577159 | 0.76 | FPR2 (0.48) | SMN1; SMN2FPR2ESR1 | |
| SCHEMBL9373441 | 0.76 | FDPS (0.34) | SMN1; SMN2FDPSFPR2MEN1KMT2A | |
| SCHEMBL2427242 | 0.75 | FDPS (0.43) | SMN1; SMN2FDPSFPR2LMNAMEN1 | |
| SCHEMBL9374488 | 0.74 | SMN1; SMN2 (0.33) | SMN1; SMN2FDPSFPR2MEN1KMT2A | |
| SCHEMBL1978411 | 0.74 | AGTR1 (0.44) | LMNANFKB1TSHRBLMPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1605752-B1 | Sulfonamides for the treatment of congestive heart failure, their compositions and uses. | CYTOKINETICS INC (US) | 2011-09-14 | — | — | EP | disclosed |