Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 4/20 | 0.49 |
| ▸ | HNF4A | P41235 | 1/20 | 0.49 |
| ▸ | GPR52 | Q9Y2T5 | 12/20 | 0.45 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24272033 | 0.90 | GPR52 (0.53) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271743 | 0.88 | ACMSD (0.49) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271862 | 0.87 | GPR52 (0.46) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271872 | 0.85 | GPR52 (0.43) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271869 | 0.85 | GPR52 (0.43) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24272034 | 0.84 | GPR52 (0.50) | ACMSDHNF4AGPR52 | |
| SCHEMBL24272035 | 0.84 | GPR52 (0.47) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271733 | 0.83 | HNF4A (0.44) | ACMSDHNF4AGPR52XDHSLC22A12 | |
| SCHEMBL24271846 | 0.83 | ACMSD (0.54) | ACMSDHNF4AXDHSLC22A12 | |
| SCHEMBL24272027 | 0.83 | ACMSD (0.44) | ACMSDHNF4AGPR52XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230348450-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION | 2023-11-02 | — | — | US | disclosed |
| US-20230348450-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION | 2023-11-02 | — | — | US | disclosed |
| WO-2022056447-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | GENZYME CORPORATION (US) | 2022-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230348450-A1 | CARBOXYLIC ACID-CONTAINING COMPOUNDS AS MODULATORS OF BIS-PHOSPHOGLYCERATE MUTASE FOR THE TREATMENT OF SICKLE CELL DISEASE | BPGM, PGAM1, PGM2 | ACMSD 253/4885HNF4A 1844/4885GPR52 2667/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.