Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | PKLR | P30613 | 1/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.48 |
| ▸ | RORC | P51449 | 11/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28626649 | 0.84 | NR1H3 (0.56) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286266 | 0.84 | PKM (0.57) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286278 | 0.83 | RORC (0.51) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286273 | 0.83 | RORC (0.51) | PKMPKLRNR1H3RORCPOLB | |
| SCHEMBL24286427 | 0.83 | PKM (0.50) | PKMPKLRNR1H3RORCNR1H2 | |
| SCHEMBL24286281 | 0.82 | PKM (0.49) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24287119 | 0.82 | PKM (0.49) | PKMPKLRNR1H3RORCHTT | |
| SCHEMBL24286476 | 0.82 | PKM (0.55) | PKMPKLRNR1H3RORCKMT2A | |
| SCHEMBL24286382 | 0.82 | PKM (0.55) | PKMPKLRRORCKMT2APAX8 | |
| SCHEMBL30110984 | 0.81 | PKM (0.62) | PKMPKLRNR1H3RORCHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3307738-B1 | ARYL DIHYDRO-2H-BENZO[B][1,4]OXAZINE SULFONAMIDE AND RELATED COMPOUNDS FOR USE AS AGONISTS OF RORY AND THE TREATMENT OF DISEASE | UNIV MICHIGAN REGENTS (US) | 2022-04-20 | — | — | EP | disclosed |