Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24287259 | 0.81 | GAA (0.56) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL26813126 | 0.81 | CRHR1 (0.44) | SMN1; SMN2CRHR1NQO2KDM4EHPGD | |
| SCHEMBL24287258 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL26817460 | 0.72 | KDM4E (0.60) | TSHRKDM4EHPGDGAAALDH1A1 | |
| SCHEMBL18796236 | 0.72 | NQO2 (0.44) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL804981 | 0.71 | TSHR (0.61) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL18796404 | 0.70 | LCK (0.52) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL18796088 | 0.70 | L3MBTL1 (0.47) | SMN1; SMN2L3MBTL1TSHRNQO2KDM4E | |
| SCHEMBL16795314 | 0.70 | ALDH1A1 (0.54) | SMN1; SMN2L3MBTL1TSHRKDM4EHPGD | |
| SCHEMBL8460913 | 0.69 | CRHR1 (0.48) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076629-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |