Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.37 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24287443 | 0.74 | LMNA (0.32) | LMNAGAARAPGEF4CRHR1 | |
| SCHEMBL24287479 | 0.73 | RAPGEF4 (0.39) | RAPGEF4FFAR4CRHR1 | |
| SCHEMBL24287546 | 0.69 | GABRP (0.31) | — | |
| SCHEMBL2107802 | 0.66 | PRSS1 (0.48) | TP53 | |
| SCHEMBL24287444 | 0.64 | — | — | |
| SCHEMBL17648477 | 0.63 | NNMT (0.38) | LMNAMAPTCRHR1 | |
| SCHEMBL29917985 | 0.63 | NNMT (0.38) | LMNAMAPTCRHR1 | |
| SCHEMBL5861890 | 0.61 | — | — | |
| SCHEMBL5844695 | 0.61 | LMNA (0.42) | LMNAGAARAPGEF4LCKTP53 | |
| SCHEMBL17648456 | 0.61 | ALDH1A1 (0.41) | LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076629-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |