Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ACP1 | P24666 | 1/20 | 0.42 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.42 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.42 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22588505 | 0.86 | ADRA1D (0.52) | GLRA1ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL29588239 | 0.86 | ADRA1D (0.52) | GLRA1ALDH1A1SMN1; SMN2HPGDTSHR | |
| SCHEMBL27688885 | 0.82 | PTGER1 (0.47) | ALDH1A1MRGPRX4MAPTMAPK1TDP1 | |
| SCHEMBL741127 | 0.81 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2HPGDTSHRALPL | |
| SCHEMBL31535739 | 0.81 | FFAR4 (0.43) | SMN1; SMN2HPGDKMT2AMEN1ADRA1D | |
| SCHEMBL29469795 | 0.80 | RXRA (0.51) | ALDH1A1SMN1; SMN2ALPLNPSR1MRGPRX4 | |
| SCHEMBL682767 | 0.79 | MAPT (0.49) | GLRA1ALDH1A1SMN1; SMN2HPGDKMT2A | |
| SCHEMBL10172543 | 0.79 | NPC1 (0.52) | GLRA1SMN1; SMN2HPGDACP1PTPN12 | |
| SCHEMBL31371876 | 0.78 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2HPGDTSHRALPL | |
| SCHEMBL1500952 | 0.78 | MAPT (0.50) | SMN1; SMN2HPGDMAPTMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |