Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316240 | 0.81 | CYP1B1 (0.41) | KDM4EKMT2AGAACASP1CASP7 | |
| SCHEMBL24315949 | 0.77 | KDM4E (0.32) | KDM4E | |
| SCHEMBL24315752 | 0.76 | HDAC8 (0.40) | KDM4EHTR6LMNA | |
| SCHEMBL24316089 | 0.74 | MAPT (0.41) | KMT2ALMNAHTTALDH1A1MAPT | |
| SCHEMBL23904907 | 0.73 | HPGD (0.35) | KDM4EKMT2AHTR6GAACASP1 | |
| SCHEMBL24621061 | 0.71 | MEN1 (0.36) | KDM4EKMT2AGAACASP1CASP7 | |
| SCHEMBL24317938 | 0.71 | ALDH1A1 (0.39) | KDM4EKMT2ALMNAUSP2ALDH1A1 | |
| SCHEMBL24317766 | 0.71 | MAPT (0.34) | KDM4EALDH1A1MAPT | |
| SCHEMBL23267569 | 0.70 | UTS2R (0.35) | — | |
| SCHEMBL27345418 | 0.67 | KDM4E (0.33) | KDM4EKMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |