Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316240 | 0.80 | CYP1B1 (0.41) | HDAC8KDM4ELMNAPOLBL3MBTL1 | |
| SCHEMBL24315949 | 0.79 | KDM4E (0.32) | KDM4E | |
| SCHEMBL24315912 | 0.76 | KDM4E (0.34) | HTR6KDM4ELMNA | |
| SCHEMBL24316089 | 0.75 | MAPT (0.41) | LMNAHTR1AL3MBTL1 | |
| SCHEMBL24317938 | 0.71 | ALDH1A1 (0.39) | KDM4ELMNAALOX15HSD17B10 | |
| SCHEMBL24317766 | 0.71 | MAPT (0.34) | KDM4E | |
| SCHEMBL24315846 | 0.70 | LMNA (0.39) | HTR6LMNAHTR1A | |
| SCHEMBL24317937 | 0.66 | KMT2A (0.41) | HDAC8LMNAPOLBL3MBTL1 | |
| SCHEMBL18666679 | 0.65 | TNF (0.43) | KDM4ELMNA | |
| SCHEMBL27345418 | 0.64 | KDM4E (0.33) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |