Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 3/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 7/20 | 0.31 |
| ▸ | PPARD | Q03181 | 3/20 | 0.31 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24317938 | 0.79 | ALDH1A1 (0.39) | MAPTNPSR1TP53RXFP1ALDH1A1 | |
| SCHEMBL24316240 | 0.76 | CYP1B1 (0.41) | MAPTHDAC6TP53RXFP1ALDH1A1 | |
| SCHEMBL24317614 | 0.71 | TDP1 (0.46) | MAPTTP53ALDH1A1KDM4E | |
| SCHEMBL24315752 | 0.71 | HDAC8 (0.40) | KDM4E | |
| SCHEMBL24315912 | 0.71 | KDM4E (0.34) | MAPTALDH1A1KDM4E | |
| SCHEMBL24315949 | 0.70 | KDM4E (0.32) | KDM4E | |
| SCHEMBL29531821 | 0.68 | CRBN (0.49) | ALDH1A1 | |
| SCHEMBL24317765 | 0.68 | CRBN (0.49) | ALDH1A1 | |
| SCHEMBL24316089 | 0.68 | MAPT (0.41) | MAPTNPSR1HDAC6ALDH1A1 | |
| SCHEMBL24317645 | 0.67 | MAPT (0.48) | MAPTALDH1A1KDM4ERORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081927-A1 | TRICYCLIC COMPOUNDS TO DEGRADE NEOSUBSTRATES FOR MEDICAL THERAPY | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |